Immunology and Immunopathogenesis of Malaria

Immunology and Immunopathogenesis of Malaria
Author(s):Jean Langhorne
Collection:Current Topics in Microbiology and Immunology
Pages:239 pages
Size:1.39 MB

[tab] [content title="Description"]Malaria is still a major global health problem, killing more than 1 million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on Sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malaria-specific mortality in young African children estimated to have doubled during the last twenty years. This increase has been associated with drug resistance of the parasite, spread of insecticide resistant mosquitoes, poverty, social and political upheaval, and lack of effective vaccines. This collection of reviews addresses many of these important issues of malarial immunity and immunopathology. They are of interest not only to malariologists, but hopefully also to the broader immunological community. Strong interactions with, and feedback from immunologists working in other infectious diseases and in basic immunology will help us to move the field of malaria immunology and therapeutic intervention forward more quickly. [/content] [content title="Content"] [/content] [content title="About the author"]Jean Langhorne is a group leader at the Francis Crick Institute. She obtained her BSc at Bedford College, University of London, and an MSc at the London School of Hygiene and Tropical Medicine. After her PhD at the Medical Research Council (MRC) Clinical Research Centre, London UK, she carried out postdoctoral training in immunology of malaria with Sydney Cohen at Guy's Hospital Medical School, London, and then moved to the Basel institute for Immunology, Switzerland. She was awarded a Fogarty fellowship to join the National Institute of Allergy and Infectious Diseases/National Institutes of Health in the USA. After four years she moved to the Max Planck Institute in Freiburg, Germany, to establish her own group. [/content] [/tab]

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