Phosphoinositide 3-kinase in Health and Disease -Volume 1

Phosphoinositide 3-kinase in Health and Disease -Volume 1
Author(s):Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt
Collection:Current Topics in Microbiology and Immunology, Volume 346
Pages:318 pages
Size:4.47 MB

[tab] [content title="Description"]PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being closely monitored; however, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here. [/content] [content title="Content"] [/content] [content title="About the author"]Christian Rommel became Executive Vice President, Global Head of Research & Development and a member of the executive committee of Bayer Pharmaceuticals in February 2021. He joined Bayer from Roche, where he was most recently Senior Vice President, Global Head of Oncology, Pharma Research and Early Development (pRED). Before that, Christian worked at Amgen where he held roles such as Vice President of External Research and Development and Vice President, Research Oncology. Previously, Christian served as Chief Scientific Officer of Intellikine from its inception to acquisition by Takeda. [/content] [/tab]

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